Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates
A novel Ru-catalyzed asymmetric transfer hydrogenation (ATH) strategy has been developed for the efficient synthesis of valuable chiral α-aminophosphonates from readily available α-iminophosphonates. This method enables the conversion of both acyclic and cyclic substrates in high yields (up to 97%) and excellent enantioselectivities (up to >99:1), providing a practical entry to phosphorus-containing chiral amines. Notably, this is the first reported application of ATH to α-iminophosphonates, offering a robust and operationally convenient alternative to conventional asymmetric hydrogenation (AH) approaches.
Authors
- Séverine Loiseau
- Tahar Ayad (ORCID: https://orcid.org/0000-0003-4210-5997)
- David Virieux (ORCID: https://orcid.org/0000-0002-6495-9478)
- Ludovic Clarion
- Pierre Plouard
- Paul Müller (ORCID: https://orcid.org/0000-0002-5790-7653)
- Laura Borrel
- Pierre‐Olivier Butin
- Rémi Cherpitel
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Montpellier (FR)
- Theranostics (New Zealand) (NZ)
- Institut Charles Gerhardt Montpellier (FR)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1002/chem.202502405
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Association Nationale de la Recherche et de la Technologie
- Université de Montpellier