Toll-like receptor 4 induces trained innate immune tolerance in the heart in a model of stress-induced cardiomyopathy
LPS pretreatment confers cardiac protection against ISO-induced injury through TLR4-mediated Type 1 and 2 interferon signalling, consistent with trained innate immune tolerance. The observation that LPS-induced protection in cardiac myocytes involves both cell-autonomous and non-cell-autonomous mechanisms underscores the complexity of innate immune tolerance in the heart, warranting further investigation into this cardioprotective phenotype.
Authors
- Junedh Amrute (ORCID: https://orcid.org/0000-0002-6851-0168)
- Kenji Rowel Q. Lim (ORCID: https://orcid.org/0000-0002-5484-4183)
- David L. Williams (ORCID: https://orcid.org/0000-0002-4586-9290)
- Abhinav Diwan (ORCID: https://orcid.org/0000-0001-7554-4772)
- Attila D Kovács (ORCID: https://orcid.org/0000-0003-2320-6434)
- Douglas L. Mann (ORCID: https://orcid.org/0000-0002-2516-0145)
Institutions
- East Tennessee State University (US)
- Washington University in St. Louis (US)
- John Cochran VA Medical Center (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1093/cvr/cvaf158
- Citations
- 5
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- Alvin J. Siteman Cancer Center
- Government of Canada
- National Institutes of Health
- Canadian Institutes of Health Research
- National Cancer Institute