NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas
These data establish a link between NOTCH3 signaling, lipid metabolic reprogramming, and ferroptosis evasion in aggressive meningioma cells. This metabolic shift may contribute to the malignant behavior observed in NOTCH3 + meningiomas, offering new insight into the biochemical vulnerabilities of these tumors.
Authors
- David Ronan Raleigh (ORCID: https://orcid.org/0000-0001-9299-8864)
- Evan C. Lien (ORCID: https://orcid.org/0000-0001-7866-4761)
- Nishanth S. Sadagopan (ORCID: https://orcid.org/0000-0001-8083-1696)
- Martha A. Cady (ORCID: https://orcid.org/0000-0001-6052-2466)
- Mark W. Youngblood (ORCID: https://orcid.org/0000-0002-1044-8015)
- Leah K. Billingham
- Catalina Lee-Chang (ORCID: https://orcid.org/0000-0002-7675-2124)
- Stephen T. Magill (ORCID: https://orcid.org/0000-0002-5257-7835)
- Tzu-Yi Chia
- Hanxiao Wan
- Jason Miska (ORCID: https://orcid.org/0000-0001-9608-2810)
- Amy B. Heimberger (ORCID: https://orcid.org/0000-0002-9970-8695)
- Susan L DeLay
- Si Wang (ORCID: https://orcid.org/0000-0002-4456-6706)
- Mateo Gomez (ORCID: https://orcid.org/0009-0007-3934-4985)
- Harrshavasan T. S. Congivaram (ORCID: https://orcid.org/0009-0003-5897-0560)
- Faith C Kaluba
Institutions
- Northwestern University (US)
- Van Andel Institute (US)
- Neurological Surgery (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1007/s11060-025-05208-5
- Primary Topic
- Cardiac tumors and thrombi
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northwestern University
- Robert H. Lurie Comprehensive Cancer Center
- National Cancer Institute