Pediatric Alpha‐Fetoprotein‐Producing Gastric Cancer Presenting With Dysphagia and Multiple Liver Tumors
AFPGC in children is extremely rare, with few reported cases. The 16-month survival observed in this case exceeds previously reported durations (8 and 4 months). Systematic evaluation of persistent gastrointestinal symptoms enabled earlier diagnosis. Standard adult gastric cancer treatment protocols appeared more effective than AFP-tumor-specific regimens, suggesting they may be optimal for pediatric AFPGC as well. Early diagnosis through detailed history-taking and prompt endoscopic examinations in children with gastrointestinal symptoms may lead to significantly prolonged survival and improved management in this rare malignancy.
Authors
- Shuichiro Uehara (ORCID: https://orcid.org/0000-0001-6542-3782)
- Yosuke Watanabe (ORCID: https://orcid.org/0000-0003-2016-3782)
- Bin Yamaoka
- Reina Hoshi (ORCID: https://orcid.org/0000-0002-1251-4944)
- Takashi Hosokawa (ORCID: https://orcid.org/0000-0003-3127-5982)
- Koji Kanezawa
- Kako Ono (ORCID: https://orcid.org/0009-0001-2355-3607)
- Ayumu Arakawa (ORCID: https://orcid.org/0009-0007-6501-7814)
- Katsuyoshi Shimozawa (ORCID: https://orcid.org/0000-0002-9285-4649)
- Takayuki Hirano (ORCID: https://orcid.org/0009-0007-7629-1886)
- Shumpei Goto (ORCID: https://orcid.org/0009-0009-7960-8206)
Institutions
- Nihon University (JP)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- National Cancer Center Hospital East (JP)
- Tokyo National Hospital (JP)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cnr2.70348
- Citations
- 1
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Japan Society for the Promotion of Science