Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer’s disease mouse model
These findings suggest a critical role for the LC-hippocampal CA1 catecholaminergic circuitry in disrupting synaptic plasticity and the spatial memory deficits characteristic of the early stages of AD. The study highlights the potential for targeting LC catecholaminergic pathways as a therapeutic strategy to improve cognitive deficits experienced by AD patients.
Authors
- Oscar Urrego-Morales (ORCID: https://orcid.org/0000-0002-4111-3285)
- Donovan K. Gálvez-Márquez (ORCID: https://orcid.org/0000-0001-6511-3733)
- Federico Bermúdez‐Rattoni (ORCID: https://orcid.org/0000-0003-2056-6119)
- Luis F. Rodríguez-Durán
Institutions
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1007/s00213-025-06885-w
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México