Distinct Blood Volume and Left Ventricular Adaptation to Severe Obesity in Middle-Aged Adults at Risk for Heart Failure
While lean mass is the primary determinant of BV, fat mass is independently associated with BV expansion and larger LVEDV. IR adults with class II/III obesity display distinct LV enlargement that is disproportionate to body size (i.e. LVEDV index) and may represent a physiologically distinct subgroup of obesity as opposed to a simple continuum of disease severity.
Authors
- Joseph Campain
- James P. MacNamara (ORCID: https://orcid.org/0000-0003-2795-6021)
- Erin J. Howden (ORCID: https://orcid.org/0000-0002-6657-4395)
- Satyam Sarma
- Christopher M. Hearon (ORCID: https://orcid.org/0000-0002-6561-3532)
- Denis J. Wakeham (ORCID: https://orcid.org/0000-0002-4200-3790)
- Benjamin D. Levine (ORCID: https://orcid.org/0000-0001-9064-7251)
- Mitchel Samels
- Michinari Hieda (ORCID: https://orcid.org/0000-0003-3434-6184)
- Katrin A. Dias (ORCID: https://orcid.org/0000-0002-2430-9219)
- Graeme Carrick‐Ranson (ORCID: https://orcid.org/0000-0003-1638-1699)
Institutions
- Baker Heart and Diabetes Institute (AU)
- University of Auckland (NZ)
- Texas Health Dallas (US)
- Presbyterian Hospital (US)
- Institute for Exercise and Environmental Medicine (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1002/ejhf.70037
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39