<i> </i>mtDNA copy number/<i>miR663/AATF</i> axis in invasive ductal carcinoma of the breast
We observed reduced expression of <i>miR663</i> and mtDNA copy number in breast tumors, along with variations in <i>AATF</i> levels across subtypes. The decrease in <i>miR663</i> could be associated with lower mtDNA copy numbers and impaired retrograde signaling, impacting <i>AATF</i> expression and function. Our findings underscore the therapeutic promise of targeting the mtDNA/miR-663/AATF axis, which could lead to advancements in breast cancer treatment.
Authors
- Shirin Shahbazi (ORCID: https://orcid.org/0000-0002-7634-5350)
- Farzaneh Dahi (ORCID: https://orcid.org/0000-0002-6136-8568)
- Loabat Geranpayeh
Institutions
- Tarbiat Modares University (IR)
- Sina Hospital (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Bioimpacts
- Published
- 2025-08-09
- DOI
- https://doi.org/10.34172/bi.30792
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Servier