Acute Anxiolytic Effects of <i>Salvia Heldreichiana</i> Essential Oil in Rats: Reduction in Serum Cortisol

This study highlighted the potential of Salvia heldreichiana essential oil as a rapid-onset anxiolytic with minimal side effects. The oil significantly reduced serum cortisol levels, a key biomarker of stress, and showed a trend toward increased serotonin levels in the hippocampus, contributing to its anxiolytic effects, paralleling mechanisms observed in conventional anxiolytic medications. Unlike many existing treatments, Salvia heldreichiana did not induce sedation or impair motor coordination, highlighting its promise as a safer alternative for anxiety management. These findings suggested the essential oil could address the unmet need for fast-acting anxiety treatments without cognitive or physical drawbacks, making it relevant for both clinical and general use.