GLP-1/GIP/GCG receptor triagonist (IUB447) enhances insulin secretion via GLP-1 receptor and Gαq signalling pathway in mice
Triagonist-induced augmentation of GSIS is primarily mediated through its interaction with the GLP-1 receptor and subsequent activation of the Gαq-TRPM5 signalling pathway. Given that Gαq is a key player in the amplification of GSIS, particularly under diabetic conditions, these findings highlight a GLP-1 receptor-centric pharmacological profile that underlies the potent effects of this multi-receptor agonist.
Authors
- Andreas Breit (ORCID: https://orcid.org/0000-0002-9343-2798)
- Peter S. Reinach (ORCID: https://orcid.org/0000-0002-3494-4523)
- Aaron Novikoff (ORCID: https://orcid.org/0000-0002-4838-001X)
- Arthur Neuberger (ORCID: https://orcid.org/0000-0002-7744-6559)
- Timo D. Müller (ORCID: https://orcid.org/0000-0002-0624-9339)
- Thomas Gudermann (ORCID: https://orcid.org/0000-0002-0323-7965)
- Philipp Beyerle (ORCID: https://orcid.org/0000-0003-1722-4919)
- Ingrid Boekhoff (ORCID: https://orcid.org/0000-0001-6399-854X)
- Pascale C. F. Schreier
- Andreas Beck (ORCID: https://orcid.org/0000-0002-2056-9005)
- Noushafarin Khajavi (ORCID: https://orcid.org/0000-0003-1337-6595)
- Alberto Cebrian Serrano
- Severin Boulassel
Institutions
- Schott (Germany) (DE)
- Wenzhou Medical University (CN)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- German Center for Lung Research (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Ludwig-Maximilians-Universität München (DE)
- Saarland University (DE)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1007/s00125-025-06525-0
- Citations
- 3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Novo Nordisk
- Ludwig-Maximilians-Universität München
- Indiana University Bloomington