Histologic Chorioamnionitis and Neurodevelopment in Preterm Infants
In this prospective, regional cohort study, exposure to moderate to severe HCA in preterm infants was independently associated with adverse motor neurodevelopment at corrected age 22 to 26 months. Causal mediation analysis suggests that HCA exhibits a significantly mediated association with neurodevelopment via induction of earlier preterm birth and a direct adverse association with neurodevelopmental outcomes. These findings suggest clinical implications for parental counseling and design of anti-inflammatory therapy trials for this high-risk population.
Authors
- Viral G. Jain (ORCID: https://orcid.org/0000-0002-1897-6461)
- Beth M. Kline‐Fath (ORCID: https://orcid.org/0000-0003-3872-9027)
- Stephanie L. Merhar (ORCID: https://orcid.org/0000-0002-3331-4220)
- Shalini Roy (ORCID: https://orcid.org/0000-0001-8053-1650)
- Laura S. Peterson (ORCID: https://orcid.org/0000-0002-4830-5271)
- Karen Harpster
- Mekibib Altaye (ORCID: https://orcid.org/0000-0002-9039-2372)
- Nehal A. Parikh (ORCID: https://orcid.org/0000-0002-1375-1247)
- Jean A. Tkach (ORCID: https://orcid.org/0000-0003-4593-7481)
- Hui Wang (ORCID: https://orcid.org/0009-0000-1266-7572)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Alabama at Birmingham (US)
- Predict (France) (FR)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.31158
- Citations
- 2
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 2.71