Phase II Dose-Randomized Study of Sunvozertinib in Platinum-Pretreated Non–Small Cell Lung Cancer With Epidermal Growth Factor Receptor Exon 20 Insertion Mutations (WU-KONG1B)
Sunvozertinib is efficacious at both 200 and 300 mg once daily in treating platinum-pretreated patients with advanced <i>EGFR</i> exon20ins NSCLC. The treatment-related adverse events of sunvozertinib were consistent with an EGFR tyrosine kinase inhibitor, with a more favorable safety profile at 200 mg than 300 mg once daily.
Authors
- A. Barba Joaquín (ORCID: https://orcid.org/0000-0003-2500-0253)
- Lorenzo Antonuzzo (ORCID: https://orcid.org/0000-0003-3349-5604)
- Xiuning Le (ORCID: https://orcid.org/0000-0002-8554-1185)
- Byoung Yong Shim (ORCID: https://orcid.org/0000-0001-6473-786X)
- Dingzhi Huang
- Yung‐Hung Luo (ORCID: https://orcid.org/0000-0002-4194-162X)
- Yanqiu Zhao (ORCID: https://orcid.org/0000-0001-6085-396X)
- Xia Song
- Jianhua Shi (ORCID: https://orcid.org/0000-0001-7009-8945)
- Dingzhi Huang (ORCID: https://orcid.org/0000-0002-2798-9459)
- Guillermo Streich
- Dae Ho Lee (ORCID: https://orcid.org/0000-0002-9749-4638)
- Joaquim Bosch‐Barrera (ORCID: https://orcid.org/0000-0002-0893-7821)
- Alessandra Bearz (ORCID: https://orcid.org/0000-0003-1020-2338)
- David Planchard (ORCID: https://orcid.org/0000-0002-1565-8310)
- M. D’Arcangelo (ORCID: https://orcid.org/0000-0003-0409-7762)
- Alexis B. Cortot (ORCID: https://orcid.org/0000-0003-0098-2238)
- Yao Yu (ORCID: https://orcid.org/0000-0002-2814-4482)
- Lyudmila Bazhenova (ORCID: https://orcid.org/0000-0001-8764-4359)
- Xingya Li (ORCID: https://orcid.org/0009-0005-0711-5702)
- Vincenzo Di Noia (ORCID: https://orcid.org/0000-0003-2009-5791)
- Ping‐Chih Hsu (ORCID: https://orcid.org/0000-0003-0173-7509)
- M. Duruisseaux (ORCID: https://orcid.org/0000-0003-1495-0966)
- François Ghiringhelli (ORCID: https://orcid.org/0000-0002-5465-8305)
- Ying Cheng (ORCID: https://orcid.org/0000-0002-8654-1443)
- Yu Jung Kim (ORCID: https://orcid.org/0000-0002-5037-0523)
- Aiping Zeng
- Héctor Soto Parrà (ORCID: https://orcid.org/0000-0001-7966-4472)
- Tsung‐Ying Yang (ORCID: https://orcid.org/0000-0003-0198-1077)
- Pasi Antero Janne (ORCID: https://orcid.org/0000-0002-7821-4928)
- Pilar Garrido (ORCID: https://orcid.org/0000-0002-5899-6125)
- Luis Paz‐Ares (ORCID: https://orcid.org/0000-0002-1947-3364)
- James Chih‐Hsin Yang (ORCID: https://orcid.org/0000-0002-5586-5138)
- Julien Mazières (ORCID: https://orcid.org/0000-0002-5921-7613)
- Li Zheng (ORCID: https://orcid.org/0000-0003-0036-1271)
- Karina Vera (ORCID: https://orcid.org/0000-0003-2669-4285)
- Gérard Zalcman
- Regan M. Memmott (ORCID: https://orcid.org/0000-0001-5881-9252)
- Laurent Greillier (ORCID: https://orcid.org/0000-0002-5807-9503)
- Zili Meng (ORCID: https://orcid.org/0000-0003-2009-7180)
- Anwen Liu (ORCID: https://orcid.org/0000-0001-5279-1068)
- Marcello Tiseo (ORCID: https://orcid.org/0000-0002-9553-8465)
- Dongqing Lv (ORCID: https://orcid.org/0000-0002-1132-0910)
- Maria J. de Miguel (ORCID: https://orcid.org/0000-0002-9366-8602)
- Nicolás Isambert (ORCID: https://orcid.org/0000-0003-3596-2114)
- Bruna Pellini (ORCID: https://orcid.org/0000-0003-0898-0202)
- G. Fernández-Hinojal (ORCID: https://orcid.org/0000-0001-7452-9183)
- Thomas John (ORCID: https://orcid.org/0000-0003-3399-5342)
- Jian Fang (ORCID: https://orcid.org/0000-0003-3697-4563)
- Enriqueta Felip (ORCID: https://orcid.org/0000-0002-7620-0098)
- Enric Carcereny (ORCID: https://orcid.org/0000-0001-5235-5602)
- Geoffrey Liu (ORCID: https://orcid.org/0000-0002-2603-7296)
- Junqiang Zhang (ORCID: https://orcid.org/0000-0003-0373-4942)
- Yun Fan (ORCID: https://orcid.org/0000-0003-1355-7513)
- Shi H (ORCID: https://orcid.org/0000-0002-9958-9892)
- Yun Fan (ORCID: https://orcid.org/0000-0003-1755-0175)
- Tae Min Kim (ORCID: https://orcid.org/0000-0001-6145-4426)
- Chien‐Chung Lin (ORCID: https://orcid.org/0000-0002-4739-5631)
- Ki Hyeong Lee (ORCID: https://orcid.org/0000-0002-3370-6275)
- Bo Jin (ORCID: https://orcid.org/0000-0003-2000-5119)
- Mengzhao Wang (ORCID: https://orcid.org/0000-0002-9226-5393)
- Bin Yang (ORCID: https://orcid.org/0000-0002-7466-3259)
- James C. Yang (ORCID: https://orcid.org/0000-0001-8935-5008)
- Jian Fang (ORCID: https://orcid.org/0000-0001-7598-1091)
- Tsung‐Ying Yang
- Chengzhi Zhou (ORCID: https://orcid.org/0000-0002-1758-0035)
- Yan Yu (ORCID: https://orcid.org/0000-0001-5598-763X)
- M. Dómine Gómez
- Lin Wu (ORCID: https://orcid.org/0000-0002-0513-8872)
- Junzhen Gao
- Jesus Corral Jaime (ORCID: https://orcid.org/0000-0003-4377-2871)
- Qunying Hong (ORCID: https://orcid.org/0009-0000-6973-2582)
- Zhangzhou Huang (ORCID: https://orcid.org/0000-0002-5873-5697)
- Juan Cundom
- Kejing Tang (ORCID: https://orcid.org/0000-0002-5454-4666)
- Yong Kek Pang
- David Vicente Baz (ORCID: https://orcid.org/0000-0002-6832-9705)
- Xiuning Le
- Jianying Zhou
- Chun SenLim
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- Peter MacCallum Cancer Centre (AU)
- Hospital Universitario La Paz (ES)
- Peking Union Medical College Hospital (CN)
- Asan Medical Center (KR)
- Hospital de Sant Pau (ES)
- Institut Gustave Roussy (FR)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Princess Margaret Cancer Centre (CA)
- Taipei Veterans General Hospital (TW)
- Seoul National University Bundang Hospital (KR)
- Moffitt Cancer Center (US)
- University of California San Diego (US)
- Taichung Veterans General Hospital (TW)
- The Catholic University of Korea St. Vincent's Hospital (KR)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Peking University Cancer Hospital (CN)
- Centre Georges François Leclerc (FR)
- Zhejiang Cancer Hospital (CN)
- Hospital Universitario Austral (AR)
- Hospital Universitario 12 De Octubre (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Institut de Cancérologie de l'Ouest (FR)
- Jinan Central Hospital (CN)
- Institut Català d'Oncologia (ES)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Beijing Chest Hospital (CN)
- Hospital Regional Universitario de Málaga (ES)
- Institut d'Investigació Biomèdica de Girona (ES)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Dana-Farber Cancer Institute (US)
- National Cancer Center (KR)
- Zhongshan Hospital (CN)
- Hôpital Larrey (FR)
- Centro di Riferimento Oncologico (IT)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- National Taiwan University Hospital (TW)
- Clinica Universidad de Navarra (ES)
- Ospedale di Parma (IT)
- Istituti Fisioterapici Ospitalieri (IT)
- Hôpital Bichat-Claude-Bernard (FR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital Universitari Germans Trias i Pujol (ES)
- Hospital Jerez Puerta del Sur (ES)
- First Affiliated Hospital of Zhengzhou University (CN)
- Zhejiang Taizhou Hospital (CN)
- Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco" (IT)
- Hôpital de la Timone (FR)
- NYU Langone’s Laura and Isaac Perlmutter Cancer Center
- The Ohio State University (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1200/jco-25-00788
- Citations
- 7
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 10.63