Mesenteric excision and Kono‐S anastomosis trial (MEErKAT): A study protocol for a multicentre, 2 × 2 factorial, randomised controlled, open‐label superiority trial
This study will robustly evaluate the efficacy of the Kono-S anastomosis technique and extended mesenteric excision in reducing endoscopic recurrence rates. The additive effect of these techniques and local tissue immune response will be investigated. This will provide important evidence to guide the optimal surgical technique and improve our understanding of the processes leading to recurrent disease.
Authors
- Laura Hancock (ORCID: https://orcid.org/0000-0002-8399-8632)
- Daniel Brice (ORCID: https://orcid.org/0000-0002-2507-3965)
- Steven R. Brown (ORCID: https://orcid.org/0000-0002-0980-2793)
- Deepak Selvakumar (ORCID: https://orcid.org/0000-0002-2058-511X)
- Esther Herbert (ORCID: https://orcid.org/0000-0002-1224-5457)
- Daniel Hind (ORCID: https://orcid.org/0000-0002-6409-4793)
- Jamie Hall (ORCID: https://orcid.org/0000-0003-4042-5591)
- Mark A. Travis (ORCID: https://orcid.org/0000-0002-8485-2272)
- Alan Lobo (ORCID: https://orcid.org/0000-0001-8037-793X)
- Stephen J. Walters (ORCID: https://orcid.org/0000-0001-9000-8126)
- Ines Rombach (ORCID: https://orcid.org/0000-0003-3464-3867)
- Olivia Hawksworth
- William Waterworth
- Lucy Sibbald
Institutions
- Manchester Academic Health Science Centre (GB)
- Royal Hallamshire Hospital (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- Cancer Research UK Manchester Institute (GB)
- Centre for Inflammation Research (GB)
- University of Sheffield (GB)
Publication Details
- Journal
- Colorectal Disease
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/codi.70212
- Citations
- 3
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Institute for Health and Care Research