Shared Genetic Architecture Among Severe Mental Disorders: A System Biology Approach Based on Protein–Protein Interaction
This study underscores the shared genetic underpinnings of severe psychiatric disorders, highlighting common biological processes, such as pro-inflammatory markers and synaptic signaling. These findings offer a transdiagnostic perspective, potentially informing novel therapeutic strategies for overlapping psychiatric conditions.
Authors
- Juan F. Gálvez‐Flórez
- Victoria Arango (ORCID: https://orcid.org/0000-0001-8811-400X)
- Isabella Gonzalez (ORCID: https://orcid.org/0009-0009-9028-3676)
- Valentina Vanegas (ORCID: https://orcid.org/0000-0002-0423-9268)
- Juan‐Manuel Anaya (ORCID: https://orcid.org/0000-0002-6444-1249)
- Hernan Felipe Guillen-Burgos (ORCID: https://orcid.org/0000-0003-1835-431X)
- Ana Milena Caicedo
- Roger S. McIntyre (ORCID: https://orcid.org/0000-0003-4733-2523)
- Wilson Terán (ORCID: https://orcid.org/0000-0002-7597-5190)
Institutions
- University of Toronto (CA)
- Pontificia Universidad Javeriana (CO)
- University of the Coast (CO)
- Universidad Simón Bolívar (CO)
- Center for Translational Molecular Medicine (NL)
- Universidad del Rosario (CO)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/brb3.70742
- Citations
- 1
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Universidad El Bosque
- Center for Clinical and Translational Research