The Relationship Between Human Cerebrospinal Fluid Proteins and the Risk of Delirium: A Study Based on Genetic Data
Our study identified a genetic causal relationship between specific cerebrospinal fluid proteins and delirium, with insulin being a key factor. We also found that cytokine-mediated signaling pathways may contribute to the pathophysiology of delirium. Future research should focus on the roles of peripheral and central glucose metabolism, as well as cellular immunity, in the pathological processes of delirium.
Authors
- Chiyi Liu
- Zhihui Xu
- Qibiao Wu (ORCID: https://orcid.org/0000-0002-1670-1050)
- Fei Ye
- Binfei Li
- Simin Zhu (ORCID: https://orcid.org/0009-0000-1962-3652)
- Zhantang Yuan (ORCID: https://orcid.org/0000-0002-3225-2769)
Institutions
- Macau University of Science and Technology (MO)
- Hennepin County (US)
- Zhongshan People's Hospital (CN)
- Zhongshan Hospital (CN)
- Zhuhai Institute of Advanced Technology (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/brb3.70836
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16