Exploring the Functional Role of Programmed Death‐Ligand 1 ( <scp>PD</scp> ‐ <scp>L1</scp> ) in the Castration‐Resistant Prostate Cancer Using Transcriptomic Sequencing Analysis
PD-L1 is upregulated in CRPC and can modulate the expression of multiple tumor-associated genes in CRPC cells. Finally, we found that PD-L1 contributes to tumor progression in CRPC by modulating the expression of SCUBE1. This study provides a theoretical basis for understanding the intracellular signaling mediated by PD-L1 and offers valuable insights into the mechanisms underlying castration resistance in prostate cancer.
Authors
- Jialin Ji (ORCID: https://orcid.org/0000-0001-9561-8409)
- Lianhong Li
- Pengxin Zhang (ORCID: https://orcid.org/0000-0002-5584-1005)
- Lin Zhong (ORCID: https://orcid.org/0000-0002-6613-7718)
- Jun Mao
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cam4.71225
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52