Digest: The effects of history on the recovery of multicellularity within <i>Saccharomyces cerevisiae</i>

What effect does evolutionary history have on the recovery of multicellularity? Khey and Travisano (2025) show that multicellularity can be recovered in all populations of their experimentally evolved Saccharomyces cerevisiae. However, the history of these cell lines changed the tempo and mode of adaptation in which these lines recovered multicellularity. These findings uncover further details on how evolutionary histories affect future trajectories and contribute another piece to the puzzle that is the predictability of evolution.