Reduced harm aversion relates to antisocial behaviors and orbitofrontal atrophy in dementia patients
Patients with behavioral variant frontotemporal dementia demonstrate reduced aversion to harming others compared to patients with AD. Reduced aversion to harming others was associated with non-aggressive behavioral changes, psychopathic personality traits, impaired empathic concern, and impaired perspective taking. Reduced aversion to harming others was associated with atrophy in the right vmPFC and OFC, specifically in medial Brodmann area 10.
Authors
- Tony X. Phan (ORCID: https://orcid.org/0000-0003-4594-7284)
- Jenifer Z. Siegel (ORCID: https://orcid.org/0000-0002-9263-1410)
- David Harold Zald (ORCID: https://orcid.org/0000-0002-1229-2923)
- Hongbo Yu (ORCID: https://orcid.org/0000-0002-3384-7772)
- R. Ryan Darby (ORCID: https://orcid.org/0000-0003-0326-1268)
- Ciaran Michael Considine (ORCID: https://orcid.org/0000-0002-8171-2821)
- Simon Vandekar (ORCID: https://orcid.org/0000-0002-7457-9073)
- Jayden J. Lee (ORCID: https://orcid.org/0000-0002-3611-4187)
- Jerica E. Reeder
Institutions
- Rutgers, The State University of New Jersey (US)
- University of California, Santa Barbara (US)
- Columbia University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70623
- Citations
- 2
- Primary Topic
- Mental Health and Psychiatry
- Type
- article
- Field-Weighted Citation Impact
- 34.53
Funders
- Alzheimer's Association
- BrightFocus Foundation
- Vanderbilt University
- Vanderbilt Institute for Clinical and Translational Research
- National Institutes of Health