Interactive effects of arterial stiffness and Alzheimer's disease risk on cognitive decline in older adults without dementia
Pulse wave velocity (PWV) was not associated with cognitive decline in any domain. Amyloid status moderated the effect of PWV on executive function and language decline. Higher PWV was associated with faster decline among amyloid-positive individuals. There was no interaction between PWV and apolipoprotein E (APOE) ε4 status on cognitive decline.
Authors
- Katherine J. Bangen (ORCID: https://orcid.org/0000-0002-1363-3179)
- Lisa Delano‐Wood (ORCID: https://orcid.org/0000-0001-5529-8703)
- Mark W. Bondi (ORCID: https://orcid.org/0000-0002-1742-3451)
- Lauren Edwards (ORCID: https://orcid.org/0000-0002-8434-9669)
- Katherine Longardner (ORCID: https://orcid.org/0000-0001-5479-2590)
- Denis S. Smirnov (ORCID: https://orcid.org/0000-0002-9768-313X)
- David P. Salmon (ORCID: https://orcid.org/0000-0003-4533-4090)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Douglas Galasko
Institutions
- San Diego State University (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70632
- Citations
- 2
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Institutes of Health
- University of California, San Diego
- National Institute on Aging