Role of Routine Duodenal Biopsy in Patients with Unexplained Iron Deficiency Anemia in Areas of Low Prevalence of Celiac Disease

Celiac disease should be considered in patients presenting with unexplained iron deficiency anemia, even if not accompanied by GI symptoms. Doing initial serological testing followed by duodenal biopsy may be an appropriate approach, especially in areas with a low prevalence of celiac disease. Routine duodenal biopsies did not seem a reasonable approach considering cost-effectiveness and its clinical utility.