Increased Risk of Surgical Site Infections With Clindamycin Prophylaxis in Clean Craniotomy
Clindamycin use is associated with an increased risk of SSI in clean craniotomy. Its bacteriostatic nature, and the proven safety of cefazolin in penicillin-allergic patients support maintaining cefazolin as the preferred antibiotic for every clean craniotomy patient. The safety of modifying prophylaxis protocols should be prospectively evaluated to optimize postoperative infection prevention.
Authors
- Bachir Belkheiri
- R Bernard (ORCID: https://orcid.org/0000-0002-7194-168X)
- Bertrand Mathon
- Vincent Jullien (ORCID: https://orcid.org/0000-0002-5971-6316)
- S. Latreille
- Vincent Degos (ORCID: https://orcid.org/0000-0002-6540-5725)
- Alice Jacquens (ORCID: https://orcid.org/0000-0002-9241-6884)
- Antoine Abi Lutfallah (ORCID: https://orcid.org/0000-0002-2808-0060)
- Anne‐Marie Korinek
- Marion Plaçais
Institutions
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1227/neu.0000000000003719
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00