Carotid endarterectomy mitigates Alzheimer's disease and non–Alzheimer's disease dementia risk linked to asymptomatic carotid stenosis
Asymptomatic extracranial carotid artery disease (aECAD) is associated with increased Alzheimer's disease (AD) and non-AD dementia risk. Limited studies have evaluated the role of carotid endarterectomy (CEA) and (carotid artery stenting (CAS) on dementia outcomes. Using United States-based insurance claims data, 487,676 patients with aECAD were evaluated. After propensity score matching, CEA was significantly associated with reduced AD risk. CAS was not significantly associated with a change in AD risk.
Authors
- Roberta Dı́az Brinton (ORCID: https://orcid.org/0000-0001-8450-772X)
- Craig Weinkauf (ORCID: https://orcid.org/0000-0001-9696-5613)
- Georgina Torrandell‐Haro (ORCID: https://orcid.org/0000-0003-2872-8282)
- Francesca Vitali (ORCID: https://orcid.org/0000-0003-2916-6402)
- Scott French (ORCID: https://orcid.org/0009-0004-1747-949X)
- Summan Zahra (ORCID: https://orcid.org/0000-0002-9185-3361)
- Juan Carlos Arias (ORCID: https://orcid.org/0000-0003-4621-9553)
Institutions
- University of Arizona (US)
- Arizona Science Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70674
- Citations
- 3
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Arizona Biomedical Research Commission
- Health Sciences, University of Arizona