Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype‐specific, and severity‐linked alterations
Plasma lipidomics reveals both shared and mutation-specific lipid alterations in frontotemporal dementia (FTD). Glucosylsphingosine is specifically elevated in FTD caused by GRN mutations and correlates with disease severity. The ganglioside GM3(d18:1_16:0) is consistently elevated across GRN, MAPT, and C9orf72 variants and correlates with disease severity. Plasma sphingolipids emerge as promising biomarkers for FTD diagnosis, subtype differentiation, and disease monitoring.
Authors
- Peter Alexander Ljubenkov (ORCID: https://orcid.org/0000-0002-3348-9215)
- Shubham Singh (ORCID: https://orcid.org/0000-0002-2428-7718)
- Tobias C. Walther (ORCID: https://orcid.org/0000-0003-1442-1327)
- Robert V. Farese (ORCID: https://orcid.org/0000-0001-8103-2239)
- Sebastian Boland (ORCID: https://orcid.org/0000-0002-6694-2039)
- Yohannes A. Ambaw (ORCID: https://orcid.org/0000-0002-1703-400X)
- Adam L. Boxer
- A. A. Hamed
Institutions
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Eli Lilly (United States) (US)
- University of California, San Francisco (US)
- Kettering University (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70631
- Citations
- 2
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health
- National Cancer Institute