Targeting the Epigenetic Remodeler GCN5 Prevents Vascular Oxidative Stress and Endothelial Dysfunction in Obesity: Insights in Patients with Cardiometabolic Disease
Our findings shed light on the importance of epigenetic regulation in obesity and pinpoint Gcn5 as a therapeutic target to prevent endothelial dysfunction in cardiometabolic disease.
Authors
- Stefano Masi (ORCID: https://orcid.org/0000-0002-7591-3686)
- Valentina Delfine
- Martin Andreas Geiger (ORCID: https://orcid.org/0000-0001-7773-5580)
- Emiliano Duranti
- Sarah Costantino (ORCID: https://orcid.org/0000-0002-3003-7213)
- Francesco Paneni (ORCID: https://orcid.org/0000-0001-6483-7844)
- Agostino Virdis (ORCID: https://orcid.org/0000-0002-6994-0223)
- Stefano Taddei
- Alessandro Mengozzi (ORCID: https://orcid.org/0000-0003-1530-8246)
- S A Mohammed (ORCID: https://orcid.org/0000-0003-2365-5037)
- Nazha Hamdani
Institutions
- Semmelweis University (HU)
- University of Pisa (IT)
- University of Zurich (CH)
- Maastricht University (NL)
- University Hospital of Zurich (CH)
- St. Josef-Hospital (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- High Blood Pressure & Cardiovascular Prevention
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1007/s40292-025-00739-4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Novartis Foundation
- Diabetes-Stiftung
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung
- Universität Zürich
- EMDO Stiftung
- Olga Mayenfisch Stiftung
- Swiss Life Stiftung für Chancenreichtum und Zukunft
- Holcim Stiftung zur Förderung der Wissenschaftlichen Fortbildung