A Novel Approach for Cisplatin‐Resistant Esophageal Squamous Cell Carcinoma via Amino Acid Transporter <scp>LAT1</scp> Inhibition
LAT1 contributes to cisplatin resistance in ESCC by sustaining amino acid metabolism and promoting mTOR-dependent autophagy. Targeting LAT1 with JPH203 enhances cisplatin sensitivity, suggesting that LAT1 inhibition could be a promising therapeutic strategy for overcoming chemoresistance in ESCC.
Authors
- Yohei Ozawa (ORCID: https://orcid.org/0000-0002-5136-8281)
- Atsushi Kunimitsu
- Narumi Harada‐Shoji (ORCID: https://orcid.org/0000-0002-7001-0541)
- Takashi Kamei (ORCID: https://orcid.org/0000-0003-1282-0463)
- Yuto Yamazaki (ORCID: https://orcid.org/0000-0002-9976-2632)
- Chiaki Sato (ORCID: https://orcid.org/0000-0003-1449-2053)
- Hirotaka Ishida (ORCID: https://orcid.org/0000-0002-6814-3564)
- Takaaki Abe (ORCID: https://orcid.org/0000-0003-3170-4660)
- Shozo Furumoto (ORCID: https://orcid.org/0000-0002-9296-3079)
- Ryoyu Niikuni
- Chyo Kobayashi
- Takeru Mozumi
- Takashi Suzuki (ORCID: https://orcid.org/0000-0002-3575-393X)
- Hiroshi Okamoto (ORCID: https://orcid.org/0000-0003-2384-4380)
- Yusuke Taniyama
- Kentaro Imai
- Iku Sasaki‐Higashimoto (ORCID: https://orcid.org/0000-0002-0724-2307)
Institutions
- Tohoku University (JP)
- Tohoku University Hospital (JP)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cam4.71234
- Citations
- 1
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Japan Society for the Promotion of Science