Simultaneous in vivo detection of spectrally resolved glutamate, glutamine, and glutathione at 3 <scp>T</scp> with <scp>NAA</scp> ‐aspartyl editing and <scp>echo‐time</scp> optimization
This technique enables simultaneous spectral resolution of glutamate, glutamine, and glutathione peaks at 3 T using difference editing of NAA-CH<sub>2</sub> and an optimized TE of 85 ms. Additionally, it demonstrates, for the first time, the feasibility of measuring <sup>13</sup>C turnovers of spectrally resolved glutamate at 3 T with the high sensitivity and spatial resolution of proton MR spectroscopy.
Authors
- Jun Shen (ORCID: https://orcid.org/0000-0003-3545-059X)
- Sungtak Hong (ORCID: https://orcid.org/0000-0003-4734-7282)
- Adriana J. Pavletic (ORCID: https://orcid.org/0000-0001-7925-2937)
- Tara Turon
- Li An (ORCID: https://orcid.org/0000-0001-8979-852X)
- Christopher S. Johnson
Institutions
- National Institutes of Health (US)
- National Institute of Mental Health (US)
Publication Details
- Journal
- Magnetic Resonance in Medicine
- Published
- 2025-09-08
- DOI
- https://doi.org/10.1002/mrm.70076
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Mental Health