Prediction of Hepatocellular Carcinoma and Other Liver‐Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction‐Associated Steatotic Liver Disease
CHB patients with metabolic dysfunction and/or MASLD are at significant risk of HCC. The PAGE-B score can be used to stratify HCC risk in this population, with negligible 5-year HCC incidence in those without cirrhosis and low PAGE-B scores. However, caution should be exercised in patients with cirrhosis in whom HCC risk remains significant even among those with a low PAGE-B score.
Authors
- R. Bart Takkenberg
- Robert A. de Man (ORCID: https://orcid.org/0000-0002-1932-7412)
- Hans Blokzijl (ORCID: https://orcid.org/0000-0003-4240-7506)
- Lesley A. Patmore (ORCID: https://orcid.org/0000-0002-2911-2140)
- Ivana Carey (ORCID: https://orcid.org/0000-0001-5806-3731)
- Bettina E. Hansen (ORCID: https://orcid.org/0000-0001-8307-3341)
- Keyur Patel (ORCID: https://orcid.org/0000-0002-4677-3127)
- Joep de Bruijne
- Douwe F. Postma (ORCID: https://orcid.org/0000-0002-0675-8459)
- Jordan J. Feld (ORCID: https://orcid.org/0000-0003-2640-2211)
- Faydra I. Lieveld (ORCID: https://orcid.org/0000-0003-4816-3530)
- Marı́a Buti (ORCID: https://orcid.org/0000-0002-0732-3078)
- Eva van Oorschot (ORCID: https://orcid.org/0000-0001-5291-4320)
- Pieter Honkoop
- Milan J. Sonneveld (ORCID: https://orcid.org/0000-0002-9253-563X)
- Kosh Agarwal (ORCID: https://orcid.org/0000-0002-4754-828X)
- Mai Kilany
- Özgür M. Koc (ORCID: https://orcid.org/0000-0003-3678-5703)
- Mark A. A. Claassen (ORCID: https://orcid.org/0000-0002-8824-3722)
- Willem Pieter Brouwer (ORCID: https://orcid.org/0000-0001-8713-1481)
- Marc van der Valk (ORCID: https://orcid.org/0000-0002-8290-6425)
- Matthijs Kramer
- Harry L.A. Janssen
Institutions
- Hebron University (PS)
- University Medical Center Groningen (NL)
- Toronto General Hospital (CA)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Albert Schweitzer Ziekenhuis (NL)
- Netherlands Center for Occupational Diseases (NL)
- Stichting HIV Monitoring (NL)
- Vall d'Hebron Hospital Universitari (ES)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- King's College Hospital (GB)
- Maastro Clinic (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1111/apt.70360
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Gilead Sciences