Epigenetic modulation of Ceratorhiza hydrophila by 5-azacytidine enhances antifungal metabolite production: insights from antimicrobial, metabolic, genomic and computational analyses

This study demonstrates that epigenetic modulation can be used to successfully unlock latent biosynthetic capability in C. hydrophila resulting in the production of unique compounds with strong and selective antifungal activity. These results demonstrate the advantages of epigenetic screening of unique fungal sources in the search for new drug leads.