Integrated single-cell and spatial transcriptomics uncover the prognostic, epigenetic, and immunological roles of FANCC in low-grade glioma
As the first-reported oncogenic driver in LGG, FANCC synergistically fuels progression via immune microenvironment reprogramming and DNA repair dysregulation, establishing its potential as a diagnostic/prognostic biomarker and therapeutic target.
Authors
- Yanzheng Gao (ORCID: https://orcid.org/0000-0002-2937-815X)
- Yusheng Chen
- Sujie Gu
- Zongye Zhang
- Xingbo Cheng (ORCID: https://orcid.org/0000-0003-3178-4138)
- Zhou Sha
- Zhendong Liu (ORCID: https://orcid.org/0000-0003-1469-1618)
- Haibo Liu (ORCID: https://orcid.org/0000-0002-4213-2883)
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1080/01616412.2025.2556255
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00