Morphine inhibits the TRPM2 signaling pathways in microglia cells, reducing the increases in oxidative stress, cytokines, and cell death caused by lipopolysaccharide
MRP reduced the levels of LPS-induced oxidative stress, inflammatory cytokines, and apoptosis <i>via</i> inhibiting TRPM2 in the BV-2 cells. One possible treatment option for oxidative microglia damage and neurological disorders induced by LPS could be the MRP.
Authors
- Mustafa Nazıroğlu (ORCID: https://orcid.org/0000-0003-0887-6974)
- Haci Ömer Osmanlıoğlu (ORCID: https://orcid.org/0000-0002-8622-6072)
Institutions
- Suleyman Demirel University (KZ)
- National Center of Public Health and Analyses (BG)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1080/08923973.2025.2555475
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68