Striatal metabolomic alterations in a mouse model of Parkinson's disease: A comprehensive liquid chromatography-mass spectrometry analysis
The striatum exhibits distinct metabolic profiles at different stages of PD, with purine metabolism showing the most pronounced alterations. The characteristic metabolites and metabolic pathways identified in this study contribute to elucidating the pathophysiological features of PD and may guide precision therapy.
Authors
- Cunjin Su (ORCID: https://orcid.org/0000-0003-3728-3377)
- Jing Dai (ORCID: https://orcid.org/0009-0000-6866-0986)
- WU Zhi-qiang
- Delai Xu
- Bo Lv (ORCID: https://orcid.org/0000-0002-2744-730X)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.ibneur.2025.08.017
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Science and Technology Program of Suzhou