Prevalence and Correlation of Age, Menopausal Status, Parity, FIGO Stage, and CA-125 Level with Estrogen and Progesterone Receptor Expression in High-Grade Serous Ovarian Cancer at Dr. Soetomo General Hospital

Background & Objective: Ovarian cancer ranks seventh among the most common malignant tumors and is the eighth leading cause of cancer-related death in women worldwide. One of the most aggressive histopathological subtypes is High-Grade Serous Epithelial Ovarian Cancer (HGSOC), often diagnosed at an advanced stage. In recent decades, the expression of hormone receptors such as Estrogen Receptor (ER) and Progesterone Receptor (PR) has been widely studied for its potential as both a prognostic factor and therapeutic target.Materials & Methods: This was an analytical observational study with a cross-sectional design using secondary data from medical records. Total sampling was employed for patients meeting the inclusion criteria. ER and PR expression were analyzed using immunohistochemistry, while clinical data included age, menopausal status, parity, CA-125 levels, and history of malignancy. Associations between variables were assessed using chi-squared and Mann-Whitney U tests with a significant threshold of P<0.05.Results: Of the 40 HGSOC cases, 85% were ER-positive and 50% were PR-positive. However, no significant associations were found between hormone receptor expression and age, parity, menopausal status, CA-125 level, staging, or family history of malignancy (P>0.05).Conclusion: Understanding ER and PR expression with clinical characteristics was not statistically significant. The studied samples were more ER positive and 50% PR positive in HGSOC cases. Further studies with larger sample sizes and more in-depth molecular approaches are needed to clarify the role of hormone receptors in the pathogenesis and management of HGSC.