SMP30 Attenuates Lens Epithelial Cells Pyroptosis of Cataract via the Downregulation of p-STAT3
The expression levels of SMP30 were downregulated in cataract cell pyroptosis. When overexpressed, SMP30 can reduce lens epithelial cell pyroptosis by downregulating the expression of p-STAT3. Thus, SMP30 demonstrates promising potential in preventing and treating cataracts.
Authors
- Chengye Tang
- Lixia Lin (ORCID: https://orcid.org/0000-0003-0409-2857)
- Tian Lan (ORCID: https://orcid.org/0009-0008-6395-9477)
- Yingqin Yang
- Yongshun Liang
- Hao Liang (ORCID: https://orcid.org/0000-0002-8239-6728)
- Qingqiao Gan
Institutions
- Guilin Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s536127
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00