Driver Genes and Genomic Instability Predict the Incidence and Outcome of Brain Metastases
Driver gene mutations are present in more than half of the patients with central nervous system (CNS) failure. Genomic instability, characterized by the number of co-occur-ring mutated genes and copy-number alterations, is a risk factor associated with shorter sur-vival time.
Authors
- Da Liu (ORCID: https://orcid.org/0000-0003-0024-6329)
- Weiping Hong (ORCID: https://orcid.org/0009-0009-9856-5854)
- Lei Wen
- Jie Ding (ORCID: https://orcid.org/0000-0001-8595-2235)
- Hui Ye (ORCID: https://orcid.org/0000-0001-7607-627X)
- Hainan Yang (ORCID: https://orcid.org/0000-0001-6864-1478)
- Xin Jin (ORCID: https://orcid.org/0000-0002-7967-3296)
- Ming Lei (ORCID: https://orcid.org/0000-0002-8099-7095)
- Tao Lin (ORCID: https://orcid.org/0000-0003-1849-1656)
- Weifang Yuan
- Qingjun Hu
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Seventh People's Hospital of Shanghai (CN)
- Guangdong 999 Brain Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-09-03
- DOI
- https://doi.org/10.2174/0115680096385277250818184435
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00