Mechanism of Tetrandrine in Ameliorating Hypoxic Pulmonary Hypertension Vascular Remodeling through Transcriptomics and Metabolomics
Our findings highlight the protective effects of TET on lung tissue in HPH mediated through the regulation of 15(S)-HPETE and 20-HETE within the arachidonic acid metabolism pathway. This regulation inhibits pulmonary angiogenesis and vasoconstriction, ultimately improving PVR in HPH.
Authors
- Min Fan (ORCID: https://orcid.org/0000-0001-9074-633X)
- Hanzhou Li (ORCID: https://orcid.org/0000-0001-6861-404X)
- Yanling Sheng (ORCID: https://orcid.org/0000-0002-7077-156X)
- Yadong Yuan (ORCID: https://orcid.org/0000-0002-1319-4743)
- Leyi Wei (ORCID: https://orcid.org/0000-0003-1444-190X)
- Junli Guo
- Huantian Cui (ORCID: https://orcid.org/0000-0002-0820-5436)
- Xixing Fang
- Xin Liu (ORCID: https://orcid.org/0000-0003-3256-2940)
- Ziping Zhang (ORCID: https://orcid.org/0000-0001-5191-007X)
- Xiaowei Gong (ORCID: https://orcid.org/0000-0002-8228-8305)
- Yaguang Wu
Institutions
- Hebei Medical University (CN)
- Tianjin University of Traditional Chinese Medicine (CN)
- American Petroleum Institute (US)
- Minzu University of China (CN)
- Hengshui University (CN)
- Yunnan University (CN)
- Wuqing District People's Hospital (CN)
- Hospital of Hebei Province (CN)
- Second Hospital of Hebei Medical University (CN)
- Minda Hospital (CN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2174/0113892002393801250812063417
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00