Successful Identification and Treatment of Cancer of Unknown Primary Originating From Gastric Cancer Using Comprehensive Genomic Profiling and Immune Checkpoint Inhibitor Therapy: A Case Report
This case highlights the critical role of CGP in the diagnosis and treatment of CUP. The use of advanced molecular techniques, including NGS, revealed the gastric origin of CUP and identified actionable biomarkers, leading to successful treatment with immune checkpoint inhibitors.
Authors
- Keitaro Takahashi (ORCID: https://orcid.org/0000-0003-4188-0246)
- Mishie Ann Tanino (ORCID: https://orcid.org/0000-0003-3370-0452)
- Yusuke Mizukami (ORCID: https://orcid.org/0000-0002-1068-7024)
- Nobuhiro Ueno (ORCID: https://orcid.org/0000-0001-5448-4766)
- Mikihiro Fujiya (ORCID: https://orcid.org/0000-0002-4321-7774)
- Sayaka Yuzawa (ORCID: https://orcid.org/0000-0002-2337-4000)
- Shin Kashima (ORCID: https://orcid.org/0000-0001-8309-4281)
- Hiroki Tanabe (ORCID: https://orcid.org/0000-0001-9029-5081)
- Kentaro Moriichi (ORCID: https://orcid.org/0000-0002-1298-3265)
- Takahiro Sasaki (ORCID: https://orcid.org/0000-0002-0412-8760)
- Katsuyoshi Ando (ORCID: https://orcid.org/0000-0003-3500-5488)
- Yusuke Ono (ORCID: https://orcid.org/0000-0001-8385-5386)
Institutions
- Asahikawa Medical University (JP)
- Sapporo Higashi Tokushukai Hospital (JP)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/cnr2.70338
- Primary Topic
- Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00