Associations between psychotic experience dimensions and polygenic liability to schizophrenia in a longitudinal birth cohort
Positive, negative and disorganised psychotic experiences are probably not strongly associated with polygenic liability to schizophrenia in this general population cohort of young adults. Self-rated negative symptoms may indicate social withdrawal/low motivation due to higher polygenic liability to affective disorders or autism, and first-rank delusions may indicate higher polygenic liability to schizophrenia, but these findings require independent confirmation.
Authors
- Stanley Zammit (ORCID: https://orcid.org/0000-0002-2647-9211)
- James Walters (ORCID: https://orcid.org/0000-0002-6980-4053)
- Alastair G. Cardno (ORCID: https://orcid.org/0000-0002-6136-5965)
- Sophie E. Legge (ORCID: https://orcid.org/0000-0001-6617-0289)
- Hein Heuvelman (ORCID: https://orcid.org/0000-0002-4662-7533)
- Hannah Jones (ORCID: https://orcid.org/0000-0002-5883-9605)
Institutions
- University of Leeds (GB)
- University of Liverpool (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Bristol City Council (GB)
- University of Bristol (GB)
- Genomics (United Kingdom) (GB)
- University Hospitals Bristol and Weston NHS Foundation Trust (GB)
- Cardiff University (GB)
Publication Details
- Journal
- BJPsych Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1192/bjo.2025.10825
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bristol
- Medical Research Council