Association between interleukin-18(TG) "rs 19465189" gene polymorphism and Helicobacter pylori infection in the southern of Iraq (Nasiriyah Province)

The study's was conducted in the south of Iraq (Nasiriyah Province), to detect relationship between (IL-18) gene polymorphism and H. pylori infections from the period 10/1/2021 to 1/3/2022, where 100 blood samples were collected H. pylori patients for the purpose of DNA extraction and identification of interleukin-18 polymorphisms . The results were as follows: The demographic and mdicale features of a whole of (100) patients were considered in this study, involving aged, sex, mean body weight, smoking, alcohol use, education, income level, and related to stomach cancer. There were 35 women and 65 men in the study group, respectively. The percentage of infection was highest in the population in rural areas, where the mean age was 53.9 10.8 years. Sequencing was performed on 30 randomly selected blood samples, and the results revealed that none of the samples had changed., Also found In this study the mutant heterozygous (TG) "rs 19465189" were associated with higher levels of IL-18 and severe gastric inflammation compared with other genotypes .The results of sequencing by Macrogen Corporation, were uis alised V.7.2.6 program by Bioedit, as well as and we made alignment using Clustal Omega tool available online. the results showed there was compatibility between recorded wolrd gene bank IL-18 polymorphism with IL-18 polymorphism in H. pylori patients in studied area.