Window of opportunity evaluation of blood–brain barrier permeability heterogeneity within and across high-grade glioma patients
This study demonstrates significant inter- and intra-tumoral heterogeneity in drug delivery for both levetiracetam and cefazolin within high-grade brain tumors that is not necessarily predicted by clinical MR imaging and may reflect tumor-induced changes in both perfusion and BBB integrity.
Authors
- Terry C. Burns (ORCID: https://orcid.org/0000-0001-7633-3045)
- Alissa Caron
- Jann Nagina Sarkaria (ORCID: https://orcid.org/0000-0001-7489-4885)
- Evanthia Galanis (ORCID: https://orcid.org/0000-0001-8014-786X)
- Angela K. Birnbaum (ORCID: https://orcid.org/0000-0002-3969-4906)
- Sani H. Kizilbash (ORCID: https://orcid.org/0000-0001-8568-1519)
- Rachael A. Vaubel (ORCID: https://orcid.org/0000-0001-8842-5975)
- Ju‐Hee Oh (ORCID: https://orcid.org/0000-0003-2864-7677)
- Minjee Kim (ORCID: https://orcid.org/0000-0002-2720-1940)
- William F. Elmquist (ORCID: https://orcid.org/0000-0002-7478-3429)
- Cécile Riviere-Cazaux (ORCID: https://orcid.org/0000-0002-8857-4345)
- Wenqiu Zhang (ORCID: https://orcid.org/0009-0001-8732-8409)
- Ian F. Parney (ORCID: https://orcid.org/0000-0002-9702-8047)
- Nathalie Y.R. Agar (ORCID: https://orcid.org/0000-0003-3149-3146)
- Afroz S. Mohammad
- J. Daniel (ORCID: https://orcid.org/0000-0002-2957-4687)
- Leland Hu (ORCID: https://orcid.org/0000-0001-9282-7619)
- Timothy J. Kaufmann (ORCID: https://orcid.org/0000-0001-7483-1569)
- Caterina Giannini (ORCID: https://orcid.org/0000-0003-2757-6782)
- Michael S. Regan (ORCID: https://orcid.org/0000-0001-5252-2829)
- Jesse G. Dixon (ORCID: https://orcid.org/0000-0002-6612-1564)
- Sílvia M. Illamola (ORCID: https://orcid.org/0000-0003-3245-1626)
- Ann C. Mladek (ORCID: https://orcid.org/0000-0002-0508-6531)
- Wenjuan Zhang (ORCID: https://orcid.org/0000-0001-6972-6449)
- Susan Geyer
- Sheldon C. Reed (ORCID: https://orcid.org/0000-0002-3266-1570)
Institutions
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1093/neuonc/noaf204
- Citations
- 3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- Yale University
- University of Minnesota
- National Cancer Institute