Causal Effects of Inflammatory Cytokines on Bipolar Disorder: A Bidirectional Two‐Sample Mendelian Randomization Study
Our findings provide robust genetic evidence supporting causal effects of elevated circulating inflammatory cytokines on BD, conferring a high susceptibility to BD. Our study emphasizes that interventions aimed at reducing peripheral inflammatory cytokine levels should be prioritized in BD management.
Authors
- J. Chen
- Peijun Ju (ORCID: https://orcid.org/0000-0002-6164-338X)
- Ying Cheng (ORCID: https://orcid.org/0009-0004-3306-5932)
- Yu Fang (ORCID: https://orcid.org/0000-0002-7536-7099)
- Meiti Wang (ORCID: https://orcid.org/0000-0002-4459-1530)
- Jinxin Zheng (ORCID: https://orcid.org/0000-0003-1476-1903)
- Jin‐jie Xu (ORCID: https://orcid.org/0000-0001-8311-2355)
Institutions
- Xinjiang Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Ruijin Hospital (CN)
- Shanghai Mental Health Center (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Beijing Anding Hospital (CN)
- Yueyang Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/brb3.70796
- Citations
- 2
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities