Comparative Effectiveness of Opioids and Opioid Substitutes on Pain and Health Related Quality of Life Among Cancer Survivors

Gabapentinoids demonstrate comparable effectiveness as opioids for pain and HRQoL in cancer survivors, supporting their use as a safer alternative. Combination therapy showed better physical function and pain control, but findings may reflect higher baseline comorbidity and limited decline capacity rather than true superiority. These results underscored the need for personalized, multimodal pain management and further research on the long-term safety of combination therapy.