Design, Synthesis, and Biological Evaluation of 8‐Phenyl‐THIQ as Antidepressive Agents
The structural modification and derivatization of natural products represent an essential pathway for pharmaceutical innovation in the management of depression. The 8-phenyl tetrahydroisoquinoline, as a parent core, was obtained from magnoflorine by a structural simplification strategy. The present report details the synthesis and antidepressant activity studies of 8-phenyl-THIQ analogs. Among them, compounds 1e and 1j exhibited significant antidepressant activity in addition to high synthetic accessibility and adequate predictive ADME/T properties.
Authors
- Wei Qiao (ORCID: https://orcid.org/0000-0003-2515-0841)
- Fan Yang (ORCID: https://orcid.org/0000-0001-8005-4997)
- Xiaopeng Wei (ORCID: https://orcid.org/0000-0002-5169-460X)
- Xingyu Huang (ORCID: https://orcid.org/0000-0003-1389-4181)
- Nuo Xu (ORCID: https://orcid.org/0009-0006-6428-8068)
Institutions
- Tianjin Medical University (CN)
Publication Details
- Journal
- Drug Development Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/ddr.70156
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00