Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice
Inhibition of cGAS improved white matter lesions and neurological dysfunction by modulating the microglial polarization towards decreased neuroinflammation and maintaining BBB integrity through STING-mediated type I IFN-β production. Thus, cGAS may be a potential therapeutic target for the treatment of GMH.
Authors
- Xuyang Zhu (ORCID: https://orcid.org/0009-0009-1568-6256)
- Y Wang
- Bing–Qiao Zhao (ORCID: https://orcid.org/0000-0002-6155-0618)
- Xiaoli Zhang (ORCID: https://orcid.org/0009-0007-1778-0612)
- Xuhui Yin
- Yiting Luo
Institutions
- Fudan University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-08-22
- DOI
- https://doi.org/10.31083/jin39286
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhengzhou University