Interrelation Of HOMA–IR and QUICKI with Anthropometry and Cardio-Metabolic Indicators in Young Adults

Background:The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) and QUICKI (Quantitative Insulin Sensitivity Check Index) are used to assess insulin resistance.Insulin resistance is accepted to be a major risk factor in the aetiology of type 2 diabetes mellitus, hypertension, dyslipidaemia, atherosclerotic vascular disease.It may be a risk factor for coronary heart disease and stroke as well.Some recent studies suggest that QUICKI can be a good alternative for HOMA-IR.With this information, we decided to investigate the cut-off values of HOMA-IR and QUICKI to assess cardiometabolic indicators in young adults.Methods: 105 samples of young adults aged 15 -25years were collected after informed written consent.The study was conducted at Dhanalakshmi Srinivasan Medical College and Hospital, following approval from the institutional research and ethics committee.It is a descriptive cross-sectional study.The study parameters include HOMA-IR, QUICKI, and lipid profile.Type 1 Diabetics, Smokers, connective tissue disorder, or those with any other metabolic disorders are excluded from the study.The obtained data were analyzed using SPSS software.Result: We found a significant positive correlation between TG and HOMA-IR, a significant negative correlation between HDL and HOMA-IR, a significant negative correlation between TG and QUICKI, and a significant positive correlation between HDL and QUICKI. Conclusion:In the study, we found no much difference between QUICKI and HOMA-IR when compared with lipid profile in young adults.