Prognostic Value of C‐Reactive Protein/Platelet Ratio as a Biomarker Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Malignant Lymphoma

Previous studies have shown that the pre-transplant C-reactive protein (CRP)/platelet ratio (CP ratio) is a predictor of survival. The aim of this multicenter retrospective study was to evaluate the clinical significance of CP ratio in patients with malignant lymphoma (ML) who underwent allogeneic hematopoietic stem cell transplantation (alloHCT). The cohort included patients with ML who underwent first alloHCT from 2007 to 2021. CP ratio was defined as CRP [mg/dL]/platelet [10<sup>4/</sup>μL] and evaluated prior to alloHCT. The cutoff value for CP ratio was set at 0.05 based on previous studies. A total of 311 cases were analyzed, of which 134 were mature B cell lymphoma, 177 were T/NK cell lymphoma (including 70 cases of adult T-cell leukemia/lymphoma), and 17 were Hodgkin's lymphoma. The median age was 53 years (range: 17-69 years). High CP ratio was associated with status of disease, presence of infections, poor performance status at alloHCT, and high transfusion volume received prior to alloHCT. Overall survival (OS) at 2 years according to CP ratio (low vs. high) was 61.1% versus 30.1% (p < 0.001), non-relapse mortality (NRM) was 21.4% versus 40.7% (p = 0.001), and the relapse rate was 23.7% versus 32.6% (p = 0.061), respectively. In multivariate analysis, the high CP ratio group was associated with poor OS (HR = 2.20, 95% CI: 1.61-3.02, p < 0.001) and higher NRM (HR = 1.90, 95% CI: 1.28-2.81, p = 0.0014). High CP ratio was found to be associated with poor post-transplant OS and NRM, and was a suitable prognostic biomarker for stratifying the risk of patients with ML who are candidates for alloHCT.

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Journal
Hematological Oncology
Published
2025-09-01
DOI
https://doi.org/10.1002/hon.70136
Primary Topic
Lymphoma Diagnosis and Treatment
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article
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article

Prognostic Value of C‐Reactive Protein/Platelet Ratio as a Biomarker Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Malignant Lymphoma

Nobuyuki Aotsuka, Masatsugu Tanaka, Hiroki Yokoyama, Masaharu Tamaki et al.
Hematological Oncology
Lymphoma Diagnosis and Treatment
article

Prognostic Value of C‐Reactive Protein/Platelet Ratio as a Biomarker Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Malignant Lymphoma

Nobuyuki Aotsuka, Masatsugu Tanaka, Hiroki Yokoyama, Masaharu Tamaki, Akihiko Izumi, Yoshinobu Kanda, Shin‐ichiro Fujiwara, Hiroto Ishii, Emiko Sakaida, Noriko Doki, Takayoshi Tachibana, Yuto Hibino, Shokichi Tsukamoto, Shinichi Kako, Daisuke Minakata, Shun‐ichi Kimura, Akira Yokota, Yuho Najima, Chikako Ohwada, Kota Yoshifuji, Takuya Miyazaki, Shingo Yano
article en

Abstract

Previous studies have shown that the pre-transplant C-reactive protein (CRP)/platelet ratio (CP ratio) is a predictor of survival. The aim of this multicenter retrospective study was to evaluate the clinical significance of CP ratio in patients with malignant lymphoma (ML) who underwent allogeneic hematopoietic stem cell transplantation (alloHCT). The cohort included patients with ML who underwent first alloHCT from 2007 to 2021. CP ratio was defined as CRP [mg/dL]/platelet [10<sup>4/</sup>μL] and evaluated prior to alloHCT. The cutoff value for CP ratio was set at 0.05 based on previous studies. A total of 311 cases were analyzed, of which 134 were mature B cell lymphoma, 177 were T/NK cell lymphoma (including 70 cases of adult T-cell leukemia/lymphoma), and 17 were Hodgkin's lymphoma. The median age was 53 years (range: 17-69 years). High CP ratio was associated with status of disease, presence of infections, poor performance status at alloHCT, and high transfusion volume received prior to alloHCT. Overall survival (OS) at 2 years according to CP ratio (low vs. high) was 61.1% versus 30.1% (p < 0.001), non-relapse mortality (NRM) was 21.4% versus 40.7% (p = 0.001), and the relapse rate was 23.7% versus 32.6% (p = 0.061), respectively. In multivariate analysis, the high CP ratio group was associated with poor OS (HR = 2.20, 95% CI: 1.61-3.02, p < 0.001) and higher NRM (HR = 1.90, 95% CI: 1.28-2.81, p = 0.0014). High CP ratio was found to be associated with poor post-transplant OS and NRM, and was a suitable prognostic biomarker for stratifying the risk of patients with ML who are candidates for alloHCT.

Hematological OncologyVol. 43(5)
Jikei University School of Medicine (JP), Tokyo Medical and Dental University (JP), Jichi Medical University (JP), Yokohama City University Medical Center (JP), Kanagawa Prefectural Hospital Organization (JP), Tokyo Metropolitan Komagome Hospital (JP), Chiba University Hospital (JP), Chiba Aoba Municipal Hospital (JP), Japanese Red Cross Narita Hospital (JP), Jichi Medical University Saitama Medical Center (JP), Kanagawa Cancer Center, International University of Health and Welfare (JP), Yokohama City University (JP)
Openalex Percentile: Top 66%
Lymphoma Diagnosis and Treatment
DOISourceOpenAlex
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