Rage gene -374T/A polymorphism in South Indian diabetic nephropathy
Diabetic nephropathy (DN) is a major complication of type 2 diabetes mellitus (T2DM) and genetic variants like RAGE -374T/A may influence disease susceptibility. Therefore, it is of interest to analyze the association between RAGE -374T/A polymorphism and DN in T2DM patients from Kolar, Karnataka. Genotyping was done by PCR-RFLP and clinical parameters were compared. No significant association was found between the polymorphism and DN (p > 0.05), though DN patients showed elevated HbA1c, microalbuminuria and dyslipidemia. These findings suggest metabolic factors, rather than this specific RAGE variant, are more strongly linked to DN risk in this population.
Authors
- Radha Rangarajan (ORCID: https://orcid.org/0000-0001-6244-2056)
- D Ponnudhali
- S Lakshmiprabha
- P. L. Pravallika
- Ramesh Babu Murikipudi
- S R Rangabashyam
Institutions
- Vinayaka Missions University (IN)
- Vinayaka Missions Medical College and Hospitals (IN)
- Government Mohan Kumaramangalam Medical College (IN)
- St. Joseph Medical Center (US)
- Tumkur University (IN)
Publication Details
- Journal
- Bioinformation
- Published
- 2025-08-31
- DOI
- https://doi.org/10.6026/973206300212288
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00