Preclinical Evaluation of Folate Receptor-α Chimeric Antigen Receptor T Cells Exhibits Highly Efficient Antitumor Activity against Osteosarcoma
FOLR1 expression has previously been implicated in the pathogenesis of treatment-resistant osteosarcoma. This report demonstrates FOLR1 expression by most osteosarcoma tumors and provides preclinical evidence of robust antitumor activity both in vitro and in vivo against xenograft osteosarcoma models exhibited by FH FOLR1-CART. These data support ongoing efforts for clinical translation of FH FOLR1-CART to an early-phase clinical trial for patients with aggressive osteosarcoma.
Authors
- Christina Root
- Cyd N. McKay (ORCID: https://orcid.org/0009-0004-5124-5750)
- Rhonda E. Ries (ORCID: https://orcid.org/0000-0002-3702-7923)
- Michelle Choe (ORCID: https://orcid.org/0000-0001-9850-9435)
- Richard Görlick (ORCID: https://orcid.org/0000-0001-8995-2929)
- Raisa Glabman (ORCID: https://orcid.org/0000-0003-1492-8830)
- Sanjay V. Malhotra (ORCID: https://orcid.org/0000-0003-4056-5033)
- Soheil Meshinchi (ORCID: https://orcid.org/0000-0002-6276-4423)
- Sarah J. Menashe (ORCID: https://orcid.org/0000-0002-6016-2592)
- Danielle Kirkey (ORCID: https://orcid.org/0000-0001-5176-9416)
- Lara Emily Davis (ORCID: https://orcid.org/0000-0002-6480-1611)
- Elizabeth T. Loggers (ORCID: https://orcid.org/0000-0003-3432-0443)
- Melia Blankenfeld
- Jack H. Peplinski (ORCID: https://orcid.org/0000-0001-5097-0652)
- Grace Hawkins
- Isabel Lira
- Brianna Wrightson (ORCID: https://orcid.org/0009-0009-6337-2198)
Institutions
- Seattle Children's Hospital (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- The University of Texas MD Anderson Cancer Center (US)
- Oregon Health & Science University (US)
- Fred Hutch Cancer Center (US)
- Seattle Children's Hospital (US)
- Center for Cancer and Blood Disorders (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0086
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- M.J. Murdock Charitable Trust
- Fred Hutchinson Cancer Research Center
- University of Washington
- National Institutes of Health
- National Cancer Institute