Integration of network toxicology, machine learning and single-cell sequencing reveals the effects of soil pollutants on prostate cancer
Various analytical methods to elucidate mechanisms by which soil pollutants contribute to prostate cancer through interactions with key molecular targets DNMT1 and mTOR. These findings inform the prevention and treatment of environmentally related cancers and provide novel insights into the molecular connection between soil pollutants and prostate cancer, and laying the groundwork for preventive and intervention strategies targeting environmentally related cancers.
Authors
- Qingfu Deng (ORCID: https://orcid.org/0009-0008-4836-9495)
- Xinyao Zhu (ORCID: https://orcid.org/0000-0002-4507-0833)
- Yang Zeng (ORCID: https://orcid.org/0000-0002-4568-9847)
- Qilong Wu
- Tao Zhou (ORCID: https://orcid.org/0000-0003-1295-8331)
- Juan Wang (ORCID: https://orcid.org/0000-0003-0767-5687)
- Zhiyu Liu (ORCID: https://orcid.org/0000-0002-6024-7836)
- Yuqi Li (ORCID: https://orcid.org/0000-0003-4629-4027)
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119010
- Citations
- 5
- Primary Topic
- Molecular Biology Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.03