Single-cell transcriptomic profiling reveals distinct tumor microenvironments in HPV-associated penile squamous cell carcinoma
Collectively, our study delineates the single-cell landscape of PSCC and highlights distinct tumor microenvironment remodeling associated with HPV status, suggesting that the reduced immunosuppression in HPV-positive tumors may underlie their more favorable prognosis.
Authors
- Wen Pan (ORCID: https://orcid.org/0009-0000-7274-2132)
- Deyun Shen
- Yong Liang (ORCID: https://orcid.org/0000-0002-3702-3113)
- Tao Tao (ORCID: https://orcid.org/0000-0003-1609-9079)
- Zhiyao Xu
- Jianqing Zhou (ORCID: https://orcid.org/0000-0001-5315-5346)
- Chen Cheng (ORCID: https://orcid.org/0000-0002-0893-1948)
- Lianbang Zhu (ORCID: https://orcid.org/0009-0003-3081-2683)
Institutions
- Wannan Medical College (CN)
- University of Science and Technology of China (CN)
- Bengbu Medical College (CN)
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- Precision Clinical Medicine
- Published
- 2025-06-28
- DOI
- https://doi.org/10.1093/pcmedi/pbaf013
- Citations
- 1
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- University of Science and Technology of China