Chronic Early-Life Obesity Linked to Childhood Impulsivity Predicts Long-Term Psychosis Trajectory Through Dose-Dependent Cerebellar Dysmaturation in 22q11.2 Deletion Syndrome
These findings suggest that metabolic dysregulation associated with obesity may link childhood behavioral impulsivity to psychosis vulnerability in 22q11DS by influencing cerebellar maturation. These findings might support preventive interventions targeting early-life metabolic trajectories in individuals at risk of psychosis.
Authors
- Samuele Cortese (ORCID: https://orcid.org/0000-0001-5877-8075)
- Corrado Sandini (ORCID: https://orcid.org/0000-0003-2933-1607)
- Maude Schneider (ORCID: https://orcid.org/0000-0001-7147-8915)
- Natacha Reich
- Stéphan Eliez (ORCID: https://orcid.org/0000-0002-8269-3028)
- Nada Kojovic (ORCID: https://orcid.org/0000-0003-0116-2485)
- Farnaz Delavari (ORCID: https://orcid.org/0000-0003-2990-4372)
- Caren Latrèche (ORCID: https://orcid.org/0000-0002-6812-2907)
- Andrea Escelsior (ORCID: https://orcid.org/0000-0002-4631-8191)
- Valeria Parlatini (ORCID: https://orcid.org/0000-0002-4754-2494)
- Silas Forrer (ORCID: https://orcid.org/0009-0007-5445-7873)
- Andrea Imparato
- Lara Pajic
Institutions
- University of Geneva (CH)
- King's College London (GB)
- Southampton Children's Hospital (GB)
- Ospedale Policlinico San Martino (IT)
- University of Southampton (GB)
- École Polytechnique Fédérale de Lausanne (CH)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.bpsc.2025.08.014
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00