Controlled Release of Parthenin: A Plausible Cytotoxic Drug Candidate

Abstract In this study, the rationale was to develop a low‐cost, effective delivery system for the controlled release of parthenin, a significant bioactive compound. By blending natural biopolymers—cellulose and tragacanth gum with glutaraldehyde (TG/CL/GA) using a solution casting method, we aimed to synthesize hydrogels with enhanced structural properties and controlled drug release behavior. This approach addresses the need for more sustainable and economical drug delivery solutions. The extent of interactions and the loading of parthenin into various blends were confirmed by FTIR spectroscopy. The surface morphology of the prepared hydrogels was determined by SEM. Further, the observed porosity in the blends encourages drug swelling and entrapment within the porous structure, yielding consistent drug delivery. Comprehensive thermal and swelling analyses and cross‐linking density measurements revealed the hydrogel's impressive water absorption, achieving good drug loading and releasing efficacy of 90%. The drug release profile followed the Peppas–Sahlin model, indicating its significance and applicability across all tested pH levels. The hemolytic evaluation of STD6 and STD3 (24.1% and 26.5%) showed moderate interaction with red blood cell membranes. These results highlight the promising potential of parthenin hydrogels as an effective localized drug delivery system.